Enough is enough: feedback control of specialized metabolism
نویسندگان
چکیده
Recent advances in our understanding of plant metabolism have highlighted the significance specialized metabolites regulation gene expression associated with biosynthetic networks. This opinion article focuses on molecular mechanisms small-molecule-mediated feedback at transcriptional level and its potential modes action, including metabolite signal perception, nature sensor, signaling transduction leading to post-transcriptional regulation, based evidence available from plants other kingdoms life. We also discuss challenges identifying occurrences, effects, localization small molecule–protein interactions. Further small-molecule-controlled metabolic fluxes will enable rational design systems engineering produce high-value metabolites.
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ژورنال
عنوان ژورنال: Trends in Plant Science
سال: 2023
ISSN: ['1878-4372', '1360-1385']
DOI: https://doi.org/10.1016/j.tplants.2023.07.012